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KMID : 0366220070420020146
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Korean Journal of Hematology
2007 Volume.42 No. 2 p.146 ~ p.150
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A Case of Pure Red Cell Aplasia Associated with Hashimoto Disease
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Kim Hoon-Gu
Lee Gyeong-Won
Kim Kwang-Min
Kang Myoung-Hee
Ju Ji-Hyun
Kang Jung-Hun
Lee Jong-Seok
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Abstract
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Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood and isolated severe erythroblastopenia with no abnormalities of the granulopoiesis and megakaryopoiesis in the bone marrow. Acquired PRCA has been reported in association with various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, mixed connective tissue disease and Sjogren’s syndrome. We report here on a case of PRCA associated with Hashimoto disease (without any other autoimmune disease) which, to the best of our knowledge, has not been previously reported in Korean and English literatures. Our patient was treated with levothyroxine alone without other immunosuppressive agents and her hemoglobin concentration and hematocrit values returned to normal. (Korean J Hematol 2007;42:146-150.)
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KEYWORD
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Pure red cell aplasia, Hashimoto disease, Autoimmune, Hypothyroidism
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